5/26/2023 0 Comments Insight pre intermediate tests pdfThese findings reveal specific endothelial and astroglial non-apoptotic caspase-9 roles in inflammation and neurovascular injury respectively and concomitant relevancy to contrast sensitivity decline. Lastly, we discovered that Astro Casp9 contributes to capillary ischemia and contrast sensitivity decline after RVO (P-RVO). One of the noted glial changes was increased levels of astroglial cl-caspase-6, which we found to be activated cell intrinsically by astroglial caspase-9 (Astro Casp9). We found that EC Casp9 is implicated in contrast sensitivity decline, induction of inflammatory cytokines, and glial reactivity. In this study, we aimed to explore the role of EC Casp9 in vision loss and inflammation. Using this model, we previously discovered that after vascular damage, there was non-apoptotic activation of endothelial caspase-9 (EC Casp9) knock-out of EC Casp9 led to a decrease in retinal edema, capillary ischemia, and neuronal death. To understand the mechanisms that contribute to neuronal death, we use a mouse model of retinal vein occlusion (RVO). Neurovascular injuries damage homeostatic communication between endothelial, pericyte, glial, and neuronal cells through signaling pathways that remain to be established. Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting unmet therapeutic needs.
0 Comments
Leave a Reply. |